Compare Anti-gammaH2ax Antibody Products from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.

X, designated γ-H2A.X, forms nuclear foci at the heavy chain constant region of cells involved in class switch recombination (CSR), a region-specific DNA reaction

Gamma‐H2AX is used widely as DNA damage marker in vitro, but its use for genotoxicity assessment in vivo has not been extensively investigated. Here, we developed an image analysis system for the precise quantification of the gamma‐H2AX signal, which we used to monitor DNA damage in animals treated with known genotoxicants (EMS, ENU and doxorubicin). Anti-Gamma H2AX (phospho-Ser139) Rabbit Monoclonal Antibody, Histone Gamma-H2A.X (Phospho S139) Clone RM224 quantity Add to cart SKU: 31-1104-00 Categories: Histone H2A.Z Acetylation , Histone Modification , Primary Antibodies , Rabbit Monoclonal Tags: 31-1104-00 , 31-1104-00-S , 31110400 , 31110400S Rabbit Polyclonal gamma H2AX Antibody Provider product page Novus Biologicals - NB100-384 Antibody type Polyclonal Description Immunogen affinity purified. The epitope maps to a region surrounding phosphorylated serine 139 of human histone H2AX.

Gamma h2ax antibody

Our preliminary tissue microarray study demonstrated that gamma-H2AX, an antibody that specifically reacts with phosphorylated histone H2AX, stained many primary RCC strongly and did not stain HCC or ACC, prompting us to evaluate its utility in these tumors and to compare it with RCC-Ma. Histone H2A.X Antibodies Histone H2A.X (H2AX) is a member of the histone H2A family which is one of the four core histones making up the nucleosome core particle. In eukaryotes, DNA double strand breaks (DSBs) have been shown to trigger the phosphorylation of serine 139 at the carboxy terminus of histone H2AX resulting in gamma-H2AX. Compare Anti-gammaH2ax Antibody Products from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more. 2010-02-04 · Quantitative detection of (125) IdU-induced DNA double-strand breaks with gamma-H2AX antibody. Radiat Res 2002; 158: 486–492.

FITC anti-H2A.X Phospho (Ser139) Antibody - H2A.X is a 14 kD basal histone and a member of the H2 histone family.

View application images and datasheets for 754 anti gamma-H2AX Antibody antibodies from 38 leading antibody suppliers, plus reviews and the top related antibodies

Histone H2AX is one of a number of core histone proteins. In the cellular response to genotoxic insults, ATM and related protein kinases phosphorylate the carboxyl-terminal tail of the H2AX protein (gamma-H2AX). gamma-H2AX marks the site of damage and provides a nucleation site for the formation of damage response and repair complexes.

Exclusively from The Antibody Resource, you can buy this Superstarter kit, which is a collection of trial sizes of these Superstar phospho-Histone H2A.x antibodies (highly rated and independently tested by us), to test using the specific experimental conditions which your research dictates, so that you can identify which will be the most appropriate for your research project.

Dillner J RET PLC gamma Phosphotyrosine Binding Domain Regulates Ca2+ Signaling and Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation. refractory DLBCL, such as antibody drug conjugates. and chimeric factors (such as PMS2 family members, H2AX, PTIP, and. TP53) as well as targets of IFNγand/or IFNγ/STAT1 signaling and upregu-.

UniProt Code History. P16104, Q4ZGJ7, Q6IAS5. Gene Synonyms. H2AX, H2a.x, H2afx, H2A/X. 2021-02-25 · p-Histone H2A.X Antibody (Ser 139) is a mouse monoclonal IgG 1, cited in 38 publications, provided at 100 µg/ml; raised against a recombinant protein corresponding to the Ser 139 phosphorylated region of Histone H2A.X of human origin I have tried 53bp1 (MAB 3802) from millipore and gamma h2ax (ab11174) from Abcam with 3.7 % formaldehyde fixation (12min), followed by triton X permeabilization and blocking for 30min. Phosphorylated H2AX (also termed, gamma-H2AX) functions to recruit and localize DNA repair proteins or cell cycle checkpoint factors to the DNA-damaged sites. In this way, phosphorylated H2AX promotes DNA repair and maintains genomic stability and thus helps prevent oncogenic transformations.
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Anti-gamma H2A.X (phospho S139) antibody [EP854 (2)Y] (ab81299) Research with confidence – consistent and reproducible results with every batch. Long-term and scalable supply – powered by recombinant technology for fast production.

gamma-H2AX marks the site of damage and provides a nucleation site for the formation of damage response and repair complexes. 2016-03-04 · Balajee, A. S. & Geard, C. R. Replication protein A and gamma-H2AX foci assembly is triggered by cellular response to DNA double-strand breaks.
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behandlings-inducerad γ-H2AX foci i arm 1 med 1000, Bethyl Laboratories) och γ-H2AX Term Safety of Nivolumab (Anti-Programmed Death 1 Antibody,.

With the autonomous radiation monitoring probe GammaTRACER, the gamma radiation dose is continually registered in the chosen time sequence. 16 Nov 2020 Learn about the value of Heavy chain only antibodies (also known as VHH antibodies, single domain antibodies, Nanobodies), and how Best-in-class setup and changeover.

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Sedelnikova OA, Rogakou EP, Panyutin IG, Bonner WM (2002) Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody. Radiat Res 158(4):486–492. ADS Article Google Scholar

Invitrogen Anti-Phospho-gamma-H2AX (Ser139) Recombinant Monoclonal (RM224), Catalog # MA5-33062.